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  • Pharmacological inhibition of phosphodiesterase 7 enhances consolidation processes of spatial memory.
    McQuown S., Paes D., Baumgärtel K., Prickaerts J. and M. Peters. Neurobiol Learn Mem. 177, 107357 (2021; Epub. Dec 3, 2020).
  • Inhibition of PDE2 and PDE4 synergistically improves memory consolidation processes.
    Paes D, Xie K, Wheeler DG, Zook D, Prickaerts J, and M. Peters Neuropharmacology. 184:108414 (2021; Epub Nov 26, 2020).
  • Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties.
    Hudson A.R., Santora V.J., Petroski R.E., Almos T.A., Anderson G., Barido R., Basinger J,, Bellows C.L., Bookser B.C., Broadbent N.J., Cabebe C., Chai C.K., Chen M., Chow S., Chung M., Heger L., Danks A.M., Freestone G.C., Gitnick D., Gupta V., Hoffmaster C., Kaplan A.P., Kennedy M.R., Lee D., Limberis J., Ly K., Mak C.C., Masatsugu B., Morse A.C., Na J., Neul D., Nikpur J., Renick J., Sebring K., Sevidal S., Tabatabaei A., Wen J., Xia S., Yan Y., Yoder Z.W., Zook D., Peters M. and J.G. Breitenbucher. Bioorg Med Chem Lett. 30, 127214 (2020; Epub Apr 25, 2020).
  • Rapid identification of a novel phosphodiesterase 7B tracer for receptor occupancy studies using LC─MS/MS.
    Chen J., Gu G., Chen M., Scott T., Heger L., Zook D., Chung D., Keenan T., Renick J., Santora V.J., Vivian J., Stauber K., Breitenbucher J.G. and A. Tabatabaei. Neurochem Int. 137, 104735 (2020; Epub Apr 1, 2020).
  • Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat.
    Gu G., Scott T., Yan Y., Warren N., Zhang A., Tabatabaei A., Xu H., Aertgeerts K., Gomez L., Morse A., Li Y.W., Breitenbucher J.G., Massari E., Vivian J. and A. Danks. Target J Pharmacol Exp Ther. 370, 399-407 (2019; Epub Jun 28, 2019). Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus. McQuown S., Xia S., Baumgärtel K., Barido R., Anderson G., Dyck B., Scott R. and M. Peters. Front Mol Neurosci. 12:21 (2019).
  • The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice.
    Peters M., Bletsch M., Stanley J., Wheeler D., Scott R. and T. Tully. Neuropsychopharmacology. 39, 2938-2948 (2019; Epub Jun 26, 2019). Effect of phosphodiesterase (1B, 2A, 9A and 10A) inhibitors on central nervous system cyclic nucleotide levels in rats and mice. Chen J., Zook D., Crickard L. and A. Tabatabaei. Neurochem Int. 129, 104471 (2019; Epub May 20, 2019).
  • Extemporaneous preparation strategy for early phase clinical studies.
    Gullapalli R.P., Mazzitelli C.L., Charriez C.M., Carpenter D.J., Crean R.D., Carter, B. and P. Perera. Int J Pharm. 549, 150-160 (2018; Epub Jul 25, 2018.) PDE4D regulates Spine Plasticity and Memory in the Retrosplenial Cortex. Baumgärtel K., Green A., Hornberger D., Lapira J., Rex C., Wheeler D.G. and M. Peters. Sci Rep. 8, 3895 (2018).
  • Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties.
    Santora V.J., Almos T.A., Barido R., Basinger J., Bellows C.L., Bookser B.C., Breitenbucher J.G., Broadbent N.J., Cabebe C., Chai C.K., Chen M., Chow S., Chung M., Crickard L., Danks A.M., Freestone G.C., Gitnick D., Gupta V., Hoffmaster C., Hudson, H.R., Kaplan A.P., Kennedy M.R., Lee D., Limberis J., Ly K., Mak C.C., Masatsugu B., Morse A.C., Na J., Neul D., Nikpur J., Peters M., Petroski R.E., Renick J., Sebring K., Sevidal S.,Tabatabaei A., Wen J., Yan Y., Yoder Z.W. and D. Zook. J Med Chem. 61, 6018-6033 (2018; Epub Jul 11, 2018).
  • Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.
    Dyck B., Branstetter B., Gharbaoui T., Hudson A.R., Breitenbucher J.G., Gomez, L., Botrous I., Marrone T., Barido R., Allerston C.K., Cedervall E.P., Xu R. and Sridhar, V., Barker R, Aertgeerts K., Schmelzer K., Neul D., Lee D., Massari M.E., Andersen C.B., Sebring K., Zhou X., Petroski R., Limberis J., Augustin M., Chun L.E., Edwards T.E., Peters M. and A. Tabatabaei. J Med Chem. 60, 3472-3483 (2019; Epub Apr 13, 2017).
  • Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.
    Gomez L., Massari M.E., Vickers T., Freestone G., Vernier W., Ly K., Xu R., McCarrick M., Marrone T., Metz M., Yan Y.G., Yoder Z.W., Lemus R., Broadbent N.J., Barido R., Warren N., Schmelzer K., Neul D., Lee D., Andersen C.B., Sebring K., Aertgeerts K., Zhou X., Tabatabaei A., Peters M. and J.G. Breitenbucher. J Med Chem. 2017 Mar 60, 2037-2051 (2017; Epub Feb 21, 2017).
  • Method for rapid optimization of recombinant GPCR protein expression and stability using virus-like particles.
    Ho T.T., Nguyen J.T., Liu J., Stanczak P., Thompson A.A., Yan Y.G., Chen J., Allerston C.K., Dillard C.L., Xu H., Shoger N.J., Cameron J.S., Massari M.E. and K. Aertgeerts. Protein Expr Purif. 133:41-49 (2017; Epub Mar 3, 2017).
  • Identification of 5-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophene-2-Carboxamides as Novel and Selective Monoamine Oxidase B Inhibitors Used to Improve Memory and Cognition.
    Kaplan A.P., Keenan T., Scott R,, Zhou X,, Bourchouladze R,, McRiner A,J,, Wilson M,E,, Romashko D,, Miller R,, Bletsch M,, Anderson G,, Stanley J,, Zhang A,, Lee D. and J. Nikpur. J. ACS Chem Neurosci. 8, 2746-2758 (2017; Epub Sep 20, 2017).
  • Dataset on Galanin Receptor 3 mutants that improve recombinant receptor expression and stability in an agonist and antagonist bound form.
    Ho T.T., Nguyen J.T., Liu J., Stanczak P., Thompson A.A., Yan Y.G., Chen J., Allerston C.K., Dillard C.L., Xu H., Shoger N.J., Cameron J.S., Massari M.E. and K. Aertgeerts. Data Brief. 4, 603-607 (2017).
  • A surrogate analyte-based liquid chromatography-tandem mass spectrometry method for the determination of endogenous cyclic nucleotides in rat brain.
    Chen J., Tabatabaei A., Zook D., Wang Y., Danks A. and K. Stauber. J Pharm Biomed Anal. 30, 146:361-368 (2017; Epub Sep 15, 2017).
  • Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.
    Rojas R.J., Edmondson D.E., Almos T., Scott R. and M.E. Massari. Bioorg Med Chem. 23, 770-778 (2015; Epub Jan 3, 2015).
  • Polyethylene glycols in oral and parenteral formulations--A critical review.
    Gullapalli R.P. and C.L. Mazzitelli Int J Pharm. 496:219-239 (2015).
  • PDE2 inhibition: potential for the treatment of cognitive disorders.
    Gomez, L. and J.G. Breitenbucher Bioorg Med Chem Lett. 15: 6522-6527 (2013).


  • Molecular basis of learning & memory.
    Bolduc F. and T. Tully In: Clinical & Scientific Aspects of Neurodevelopmental Disabilities, M.I. Shevell (Ed), International Review of Child Neurology, MacKeith Press, London (2009).
  • Fruit flies and intellectual disability.
    Bolduc F. and T. Tully Fly (Austin) 3: 91-104 (2009).
  • Refining the roles of GABAergic signaling during neural circuit formation.
    Ackerman C.J. and H.T. Cline Trends in Neurosciences 30: 392-389 (2007).
  • Genetics in Learning and Memory
    Wang Y., Dubnau J., Tully T., and Y. Zhong In: Neurobiology of Learning and Memory, Second Edition, Kesner, R.P. and Martinez, J. (Eds), Elsevier. 103-124 (2007).
  • Deconstructing Memory in Drosophila.
    Margulies C., Tully T. and J. Dubnau Current Biology 15: R700-R713 (2005).


  • Neurogenetic dissection of conditioned behavior: evolution by analogy or homology?
    J. Dubnau Journal of Neurogenetics 17: 295-326 (2003).
  • Reply: The myth of a myth
    T. Tully Current Biology 13: R426 (2003).
  • Pavlov's flies
    T. Tully Current Biology 13: R117-119 (2003).
  • Memories are Made of This: How memory works in humans and animals.
    R. Bourtchouladze Columbia University Press (2002).
  • CREB and the Discovery of Cognitive Enhancers.
    Scott R., Bourtchouladze R., Gossweiler S., Dubnau J. and T. Tully Journal of Molecular Neuroscience 19: 171-177 (2002).
  • Long term memory is facilitated by cAMP response element binding protein overexpression in the amygdala.
    Josselyn S. A., Shi C., Carlezon W. A., Neve R. L., Nestler E. J. and M. Davis Journal of Neuroscience 21: 2404-2412 (2001).
  • nalyot, a mutation of the Drosophila Myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory.
    DeZazzo J., Sandstrom D., de Belle S., Velinzon K., Smith P., Grady L., Del Vecchio M., Ramaswami M. and T. Tully Neuron 27: 145-158 (2000).
  • Drosophila DCV detection and eradication protocols
    Referenced in: Sullivan W., Ashburner M. and Hawley R.S. Drosophila Protocols. Cold Spring Harbor Laboratory Press, Cold Spring Harbor NY. p. 595 (2000).
  • Different training procedures for contextual memory in mice can recruit either one or two critical periods for memory consolidation that require protein synthesis and PKA.
    Bourtchouladze R., Abel T., Berman A., Gordon R., Lapidus K. and E. R. Kandel. Learning Mem. 5, 365-375 (1998).
  • Rolipram, a Type IV-specific Phosphodiesterase Inhibitor, Facilitates the Establishment of Long Lasting Long-Term Potentiation and Improves Memory.
    Barad M., Bourtchouladze R., Winder D., Golan H. and Kandel E. R. Proc. Natl. Acad. Sci. U.S.A. 95, 15020-15025 (1998).
  • CREB as a memory modulator: induced expression of an hsp-dCREB2-a activator isoform enhances the formation of long-term memory.
    Yin J.C.P., Del Vecchio M., Zhou H. and T. Tully Cell 81, 107-115 (1995).
  • Deficient long-term memory in mice with a targeted mutation of the cAMP responsive element binding protein.
    Bourtchouladze R.A., Franguelli B., Bendy J., Cioffi D., Schutz G. and A. J. Silva. Cell 79: 59-68 (1994).
  • Induction of a dominant-negative CREB transgene specifically blocks long-term memory in Drosophila.
    Yin J.C.P., Wallach J.S., Del Vecchio M., Wilder E.L., Zhou H., Quinn W.G. and T. Tully Cell 79: 49-57 (1994).
  • Genetic dissection of consolidated memory in Drosophila melanogaster
    Tully T., Preat T., Boynton S.C. and M. Del Vecchio Cell 79: 35-47 (1994).